Category 28
Baseline: Assessment ⏵ Genomics ⏵ Genetic risk scores ⏵ Type 2 diabetes

Description

This category contains genetic risk scores for type 2 diabetes (T2D) based on Suzuki et. al 2023 (preprint) and used in Publication 27.

Suzuki, K., Hatzikotoulas, K., Southam, L. et al. Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications. medRxiv 2023.03.31.23287839; doi: doi.org/10.1101/2023.03.31.23287839

One overall score uses the trans-ancestry weights (Supplementary Table 4) and another uses the Hispanic weights (Supplementary Table 5). Cluster-specific scores for clusters (Supplementary Table 10):

• Beta cell +PI
• Beta cell -PI
• Residual Glycaemic
• Body fat
• Metabolic syndrome
• Obesity
• Lipodystrophy
• Liver/lipid metabolism

For a list of SNPs, including those eventually included in the overall scores, see Resource 111.