| Title: | Prediabetes and Risk of All-Cause and Cause-Specific Mortality: A Prospective Study of 114 062 Adults in Mexico City |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 10 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40208106/ |
| DOI: | https://doi.org/10.1210/clinem/dgaf225 |
| URL: | https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgaf225/62904463/dgaf225.pdf |
Publication 26
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Abstract
BACKGROUND: Prediabetes has been associated with increased all-cause and cardiovascular mortality. However, no large-scale studies have been conducted in Mexico or Latin America examining these associations.
METHODS: We analyzed data from 114062 adults without diabetes (diagnosed or undiagnosed) from the Mexico City Prospective Study. Participants were followed until January 1, 2021, for cause-specific mortality. We defined prediabetes according to the American Diabetes Association (ADA; HbA1c ≥5.7% to <6.5%) and the International Expert Committee (IEC; HbA1c ≥6.0 to <6.5%) definitions. Cox regression adjusted for confounders was used to estimate all-cause and cause-specific mortality rate ratios (RR) for deaths occurring at ages 35 to 74 years associated with prediabetes.
RESULTS: After median 18.4 (IQR 17.6-19.7) years of follow-up, individuals with prediabetes had higher risk of all-cause mortality at ages 35 to 74 compared to those without prediabetes (RR 1.13 [1.07-1.20] for ADA-defined and 1.27 [1.17-1.38] for IEC-defined prediabetes), as well as higher risk of cardiovascular (RR 1.23 [1.11-1.37] and 1.44 [1.24-1.67], respectively), renal (RR 1.33 [1.06-1.66] and 1.62 [1.18-2.23], respectively), and acute diabetic deaths (RR 2.62 [1.75-3.93] and 3.42 [2.09-5.61], respectively). The absolute excess risk associated with ADA-defined prediabetes at ages 35 to 74 accounted for 7% of cardiovascular, 9% of renal, and 31% of acute diabetic deaths. IEC-defined prediabetes accounted for 4%, 5% and 14% of cardiovascular, renal, and acute diabetic deaths. Prediabetes-associated excess mortality risks were, at least in part, explained by adiposity.
CONCLUSION: Prediabetes is a significant risk factor for all-cause, cardiovascular, renal, and acute diabetic deaths in Mexican adults. Early identification and timely management of prediabetes among individuals at risk of this condition could reduce premature mortality in this population.
22 Authors
- Carlos Alberto Fermín-Martínez
- Omar Yaxmehen Bello-Chavolla
- César Daniel Paz-Cabrera
- Daniel Ramírez-García
- Jerónimo Perezalonso-Espinosa
- Luisa Fernández-Chirino
- Arsenio Vargas-Vázquez
- Juan Pablo Díaz-Sánchez
- Padme Nailea Méndez-Labra
- Alejandra Núñez-Luna
- Martín Roberto Basile-Alvarez
- Paulina Sánchez-Castro
- Fiona Bragg
- Louisa Gnatiuc Friedrichs
- Diego Aguilar-Ramírez
- Jonathan R Emberson
- Jaime Berumen
- Pablo Kuri-Morales
- Roberto Tapia-Conyer
- Jesus Alegre-Díaz
- Jacqueline A Seiglie
- Neftali Eduardo Antonio-Villa