| Title: | La compleja relación entre la ancestría amerindia y la obesidad en la población mexicana |
| Journal: | Gaceta Medica de Mexico |
| Published: | 1 Apr 2025 |
| DOI: | https://doi.org/10.24875/gmm.24000439 |
| URL: | https://www.gacetamedicademexico.com/files/gmm_439_24_compleja.pdf |
Publication 34
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Abstract
ResumenLa alta prevalencia de obesidad en las poblaciones mexicoamericanas en Estados Unidos ha sugerido que la composicion genetica diferente de la poblacion mexicana podria estar relacionada con la alta prevalencia de obesidad en Mexico. Recientemente, se exploro el genoma de 140 000 individuos en la cohorte Estudio Prospectivo de la Ciudad de Mexico (MCPS,Mexico City Prospective Study) y se encontro que el promedio de ancestria amerindia (AMR) fue de 66.2 %, seguida de las ancestrias europea (29.2 %), africana (3.7 %) y asiatica (0.8 %). Sin embargo, las proporciones de ancestria varian segun la region geografica del pais, observandose un gradiente creciente de AMR de norte a sur. A pesar de la importancia de esta relacion, existen pocos estudios que han analizado la relacion entre obesidad y AMR; ademas, los resultados soncontroversiales. La relacion entre AMR y obesidad central ha sido mas consistente, especialmente en mujeres. Se han encontrado pocas variantes geneticas asociadas a la obesidad en Mexico, debido principalmente al reducido numero de individuos estudiados. Analisis futuros de la cohorte MCPS seguramente permitiran esclarecer con precision la relacion entre AMR y obesidad, e identificar variaciones geneticas y genes especificos del genoma amerindio asociados a la obesidad y a otras enfermedades metabolicas.
Abstract
The high prevalence of obesity in Mexican-American populations in the United States has suggested that the different genetic composition of the Mexican population may be related to the high prevalence of obesity in Mexico. Recently, the genome of 140,000 individuals in the Mexico City Prospective Study (MCPS) cohort was explored, and it was found that the average Amerindian ancestry (AMR) was 66.2%, followed by European (29.2%), African (3.7%), and Asian (0.8%) ancestries. However, the proportions of ancestry vary by geographic region of the country, with an increasing gradient of AMR from north to south. Despite the importance of this relationship, there are few studies that have analyzed the relationship between obesity and AMR, and the results are controversial. The relationship between AMR and central obesity has been more consistent, especially in women. Few genetic variants associated with obesity have been found in Mexico, due to the small number of individuals analyzed. Future analysis of the MCPS cohort will likely clarify the relationship between AMR and obesity, and identify genetic variations and genes associated with obesity and other metabolic diseases, specific to the Amerindian genome.
14 Authors
- Paulina Baca
- Elizabeth Barrera
- Pablo A. Kuri
- Jason Torres
- Carlos González-Carballo
- Alberto Zarza
- Fernando Rivas
- Georgina Del Vecchyo
- Oscar Pérez-Flores
- Carlos A. Pantoja
- Jonathan Emberson
- Jesús Alegre-Díaz
- Roberto Tapia-Conyer
- Jaime Berumen