NSHD46 : Category 2012

Category 2012
Biological samples ⏵ Blood assays ⏵ NMR metabolomics

Description

NMR metabolic biomarkers generated by Nightingale Health. Data is currently available for Phase 1 and Phase 2 of the study, measuring 251 metabolic biomarkers for EDTA plasma samples from approx 280,000 participants. Metabolic biomarkers were measured from randomly selected EDTA plasma samples (aliquot 3) using a high-throughput NMR-based metabolic biomarker profiling platform developed by Nightingale Health Ltd. The measurements took place between June 2019 and April 2020 (Phase 1) and April 2020 and June 2022 (Phase 2) using eight spectrometers at Nightingale Health, based in Finland. The biomarkers span multiple metabolic pathways, including lipoprotein lipids in 14 subclasses, fatty acids and fatty acid compositions, as well as various low-molecular weight metabolites, such as amino acids, ketone bodies, and glycolysis metabolites quantified in molar concentration units. Previously available data from Phase 1 of the study has been updated as a part of the July 2023 release due to updates in spectrometer recalibration (further information can be found inResource 130). Currently available data is not final and may be updated due to recalibration and normalisation procedures before the project completes.

Field ID	Description
2733	18:2, linoleic acid (mmol/l)
2664	22:6, docosahexaenoic acid (mmol/l)
2657	3_hydroxybutyrate (mmol/l)
2651	Acetate (mmol/l)
2650	Acetoacetate (mmol/l)
2652	Alanine (mmol/l)
2653	Albumin (signal area)
2654	Apolipoprotein A_I (g/l)
2655	Apolipoprotein B (g/l)
2686	Cholesterol esters in IDL (mmol/l)
2880	Cholesterol esters in chylomicrons and extremely large VLDL (mmol/l)
2699	Cholesterol esters in large HDL (mmol/l)
2711	Cholesterol esters in large LDL (mmol/l)
2723	Cholesterol esters in large VLDL (mmol/l)
2742	Cholesterol esters in medium HDL (mmol/l)
2754	Cholesterol esters in medium LDL (mmol/l)
2766	Cholesterol esters in medium VLDL (mmol/l)
2787	Cholesterol esters in small HDL (mmol/l)
2799	Cholesterol esters in small LDL (mmol/l)
2811	Cholesterol esters in small VLDL (mmol/l)
2844	Cholesterol esters in very large HDL (mmol/l)
2856	Cholesterol esters in very large VLDL (mmol/l)
2868	Cholesterol esters in very small VLDL (mmol/l)
2687	Cholesterol esters to total lipids ratio in IDL (%)
2881	Cholesterol esters to total lipids ratio in chylomicrons and extremely large VLD
2700	Cholesterol esters to total lipids ratio in large HDL (%)
2712	Cholesterol esters to total lipids ratio in large LDL (%)
2724	Cholesterol esters to total lipids ratio in large VLDL (%)
2743	Cholesterol esters to total lipids ratio in medium HDL (%)
2755	Cholesterol esters to total lipids ratio in medium LDL (%)
2767	Cholesterol esters to total lipids ratio in medium VLDL (%)
2788	Cholesterol esters to total lipids ratio in small HDL (%)
2800	Cholesterol esters to total lipids ratio in small LDL (%)
2812	Cholesterol esters to total lipids ratio in small VLDL (%)
2845	Cholesterol esters to total lipids ratio in very large HDL (%)
2857	Cholesterol esters to total lipids ratio in very large VLDL (%)
2869	Cholesterol esters to total lipids ratio in very small VLDL (%)
2658	Citrate (mmol/l)
2691	Concentration of IDL particles (mol/l)
2885	Concentration of chylomicrons and extremely large VLDL particles (mol/l)
2704	Concentration of large HDL particles (mol/l)
2716	Concentration of large LDL particles (mol/l)
2728	Concentration of large VLDL particles (mol/l)
2747	Concentration of medium HDL particles (mol/l)
2759	Concentration of medium LDL particles (mol/l)
2771	Concentration of medium VLDL particles (mol/l)
2792	Concentration of small HDL particles (mol/l)
2804	Concentration of small LDL particles (mol/l)
2816	Concentration of small VLDL particles (mol/l)
2849	Concentration of very large HDL particles (mol/l)
2861	Concentration of very large VLDL particles (mol/l)
2873	Concentration of very small VLDL particles (mol/l)
2659	Conjugated linoleic acid (mmol/l)
2661	Creatinine (mmol/l)
2662	Diacylglycerol (mmol/l)
2666	Esterified cholesterol (mmol/l)
2837	Estimated degree of unsaturation
2667	Estimated description of fatty acid chain length, not actual carbon number
2672	Free cholesterol (mmol/l)
2688	Free cholesterol in IDL (mmol/l)
2882	Free cholesterol in chylomicrons and extremely large VLDL (mmol/l)
2701	Free cholesterol in large HDL (mmol/l)
2713	Free cholesterol in large LDL (mmol/l)
2725	Free cholesterol in large VLDL (mmol/l)
2744	Free cholesterol in medium HDL (mmol/l)
2756	Free cholesterol in medium LDL (mmol/l)
2768	Free cholesterol in medium VLDL (mmol/l)
2789	Free cholesterol in small HDL (mmol/l)
2801	Free cholesterol in small LDL (mmol/l)
2813	Free cholesterol in small VLDL (mmol/l)
2846	Free cholesterol in very large HDL (mmol/l)
2858	Free cholesterol in very large VLDL (mmol/l)
2870	Free cholesterol in very small VLDL (mmol/l)
2689	Free cholesterol to total lipids ratio in IDL (%)
2883	Free cholesterol to total lipids ratio in chylomicrons and extremely large VLDL
2702	Free cholesterol to total lipids ratio in large HDL (%)
2714	Free cholesterol to total lipids ratio in large LDL (%)
2726	Free cholesterol to total lipids ratio in large VLDL (%)
2745	Free cholesterol to total lipids ratio in medium HDL (%)
2757	Free cholesterol to total lipids ratio in medium LDL (%)
2769	Free cholesterol to total lipids ratio in medium VLDL (%)
2790	Free cholesterol to total lipids ratio in small HDL (%)
2802	Free cholesterol to total lipids ratio in small LDL (%)
2814	Free cholesterol to total lipids ratio in small VLDL (%)
2847	Free cholesterol to total lipids ratio in very large HDL (%)
2859	Free cholesterol to total lipids ratio in very large VLDL (%)
2871	Free cholesterol to total lipids ratio in very small VLDL (%)
2673	Glucose (mmol/l)
2674	Glutamine (mmol/l)
2675	Glycerol (mmol/l)
2676	Glycine (mmol/l)
2677	Glycoprotein acetyls, mainly a1_acid glycoprotein (mmol/l)
2826	High lactate
2827	High pyruvate
2683	Histidine (mmol/l)
2696	Isoleucine (mmol/l)
2734	Lactate (mmol/l)
2739	Leucine (mmol/l)
2828	Low glucose
2830	Low glutamine / high glutamate
2829	Low protein content
2679	Mean diameter for HDL particles (nm)
2737	Mean diameter for LDL particles (nm)
2840	Mean diameter for VLDL particles (nm)
2776	Monounsaturated fatty acids; 16:1, 18:1 (mmol/l)
2668	Omega_3 fatty acids (mmol/l)
2670	Omega_6 fatty acids (mmol/l)
2780	Phenylalanine (mmol/l)
2779	Phosphatidylcholine and other cholines (mmol/l)
2692	Phospholipids in IDL (mmol/l)
2886	Phospholipids in chylomicrons and extremely large VLDL (mmol/l)
2705	Phospholipids in large HDL (mmol/l)
2717	Phospholipids in large LDL (mmol/l)
2729	Phospholipids in large VLDL (mmol/l)
2748	Phospholipids in medium HDL (mmol/l)
2760	Phospholipids in medium LDL (mmol/l)
2772	Phospholipids in medium VLDL (mmol/l)
2793	Phospholipids in small HDL (mmol/l)
2805	Phospholipids in small LDL (mmol/l)
2817	Phospholipids in small VLDL (mmol/l)
2850	Phospholipids in very large HDL (mmol/l)
2862	Phospholipids in very large VLDL (mmol/l)
2874	Phospholipids in very small VLDL (mmol/l)
2693	Phospholipids to total lipds ratio in IDL (%)
2887	Phospholipids to total lipds ratio in chylomicrons and extremely large VLDL (%)
2706	Phospholipids to total lipds ratio in large HDL (%)
2718	Phospholipids to total lipds ratio in large LDL (%)
2730	Phospholipids to total lipds ratio in large VLDL (%)
2749	Phospholipids to total lipds ratio in medium HDL (%)
2761	Phospholipids to total lipds ratio in medium LDL (%)
2773	Phospholipids to total lipds ratio in medium VLDL (%)
2794	Phospholipids to total lipds ratio in small HDL (%)
2806	Phospholipids to total lipds ratio in small LDL (%)
2818	Phospholipids to total lipds ratio in small VLDL (%)
2851	Phospholipids to total lipds ratio in very large HDL (%)
2863	Phospholipids to total lipds ratio in very large VLDL (%)
2875	Phospholipids to total lipds ratio in very small VLDL (%)
2831	Plasma sample
2781	Polyunsaturated fatty acids (mmol/l)
2783	Pyruvate (mmol/l)
2778	QC variable for issues with processing
2735	Ratio of 18:2 linoleic acid to total fatty acids (%)
2665	Ratio of 22:6 docosahexaenoic acid to total fatty acids (%)
2656	Ratio of apolipoprotein B to apolipoprotein A_I
2660	Ratio of conjugated linoleic acid to total fatty acids (%)
2663	Ratio of diacylglycerol to triglycerides
2777	Ratio of monounsaturated fatty acids to total fatty acids (%)
2669	Ratio of omega_3 fatty acids to total fatty acids (%)
2671	Ratio of omega_6 fatty acids to total fatty acids (%)
2782	Ratio of polyunsaturated fatty acids to total fatty acids (%)
2824	Ratio of saturated fatty acids to total fatty acids (%)
2832	Ratio of triglycerides to phosphoglycerides
2784	Remnant cholesterol (non-HDL, non-LDL -cholesterol) (mmol/l)
2823	Saturated fatty acids (mmol/l)
2821	Serum total cholesterol (mmol/l)
2822	Serum total triglycerides (mmol/l)
2825	Sphingomyelins (mmol/l)
2678	Total cholesterol in HDL (mmol/l)
2681	Total cholesterol in HDL2 (mmol/l)
2682	Total cholesterol in HDL3 (mmol/l)
2684	Total cholesterol in IDL (mmol/l)
2736	Total cholesterol in LDL (mmol/l)
2839	Total cholesterol in VLDL (mmol/l)
2878	Total cholesterol in chylomicrons and extremely large VLDL (mmol/l)
2697	Total cholesterol in large HDL (mmol/l)
2709	Total cholesterol in large LDL (mmol/l)
2721	Total cholesterol in large VLDL (mmol/l)
2740	Total cholesterol in medium HDL (mmol/l)
2752	Total cholesterol in medium LDL (mmol/l)
2764	Total cholesterol in medium VLDL (mmol/l)
2785	Total cholesterol in small HDL (mmol/l)
2797	Total cholesterol in small LDL (mmol/l)
2809	Total cholesterol in small VLDL (mmol/l)
2842	Total cholesterol in very large HDL (mmol/l)
2854	Total cholesterol in very large VLDL (mmol/l)
2866	Total cholesterol in very small VLDL (mmol/l)
2685	Total cholesterol to total lipids ratio in IDL (%)
2879	Total cholesterol to total lipids ratio in chylomicrons and extremely large VLDL
2698	Total cholesterol to total lipids ratio in large HDL (%)
2710	Total cholesterol to total lipids ratio in large LDL (%)
2722	Total cholesterol to total lipids ratio in large VLDL (%)
2741	Total cholesterol to total lipids ratio in medium HDL (%)
2753	Total cholesterol to total lipids ratio in medium LDL (%)
2765	Total cholesterol to total lipids ratio in medium VLDL (%)
2786	Total cholesterol to total lipids ratio in small HDL (%)
2798	Total cholesterol to total lipids ratio in small LDL (%)
2810	Total cholesterol to total lipids ratio in small VLDL (%)
2843	Total cholesterol to total lipids ratio in very large HDL (%)
2855	Total cholesterol to total lipids ratio in very large VLDL (%)
2867	Total cholesterol to total lipids ratio in very small VLDL (%)
2833	Total cholines (mmol/l)
2834	Total fatty acids (mmol/l)
2690	Total lipids in IDL (mmol/l)
2884	Total lipids in chylomicrons and extremely large VLDL (mmol/l)
2703	Total lipids in large HDL (mmol/l)
2715	Total lipids in large LDL (mmol/l)
2727	Total lipids in large VLDL (mmol/l)
2746	Total lipids in medium HDL (mmol/l)
2758	Total lipids in medium LDL (mmol/l)
2770	Total lipids in medium VLDL (mmol/l)
2791	Total lipids in small HDL (mmol/l)
2803	Total lipids in small LDL (mmol/l)
2815	Total lipids in small VLDL (mmol/l)
2848	Total lipids in very large HDL (mmol/l)
2860	Total lipids in very large VLDL (mmol/l)
2872	Total lipids in very small VLDL (mmol/l)
2835	Total phosphoglycerides (mmol/l)
2680	Triglycerides in HDL (mmol/l)
2694	Triglycerides in IDL (mmol/l)
2738	Triglycerides in LDL (mmol/l)
2841	Triglycerides in VLDL (mmol/l)
2888	Triglycerides in chylomicrons and extremely large VLDL (mmol/l)
2707	Triglycerides in large HDL (mmol/l)
2719	Triglycerides in large LDL (mmol/l)
2731	Triglycerides in large VLDL (mmol/l)
2750	Triglycerides in medium HDL (mmol/l)
2762	Triglycerides in medium LDL (mmol/l)
2774	Triglycerides in medium VLDL (mmol/l)
2795	Triglycerides in small HDL (mmol/l)
2807	Triglycerides in small LDL (mmol/l)
2819	Triglycerides in small VLDL (mmol/l)
2852	Triglycerides in very large HDL (mmol/l)
2864	Triglycerides in very large VLDL (mmol/l)
2876	Triglycerides in very small VLDL (mmol/l)
2695	Triglycerides to total lipids ratio in IDL (%)
2889	Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL (%)
2708	Triglycerides to total lipids ratio in large HDL (%)
2720	Triglycerides to total lipids ratio in large LDL (%)
2732	Triglycerides to total lipids ratio in large VLDL (%)
2751	Triglycerides to total lipids ratio in medium HDL (%)
2763	Triglycerides to total lipids ratio in medium LDL (%)
2775	Triglycerides to total lipids ratio in medium VLDL (%)
2796	Triglycerides to total lipids ratio in small HDL (%)
2808	Triglycerides to total lipids ratio in small LDL (%)
2820	Triglycerides to total lipids ratio in small VLDL (%)
2853	Triglycerides to total lipids ratio in very large HDL (%)
2865	Triglycerides to total lipids ratio in very large VLDL (%)
2877	Triglycerides to total lipids ratio in very small VLDL (%)
2836	Tyrosine (mmol/l)
2838	Valine (mmol/l)

Description

240 Data-Fields

1 Parent Category